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Webinar non ECM in ingleseRAZIONALE
Objectives: This course aims to introduce participants to the fundamental concepts of TWAS, an innovative methodology for identifying associations between gene expression and complex traits. The specific objectives include:
• Understanding the basic principles of TWAS and how it differs from GWAS.
• Learning to conduct TWAS analysis using software and gene expression data.
• Exploring practical applications of TWAS in human genetic research.
PROGRAMMA
15:30 Opening of the proceedings
Mario Capasso: Leader of Working Group of Multifactorial Diseases
15:45 Session 1 – Fundamentals and Statistical Methods of TWAS – Mauro Pala, CNR Cagliari
- Introduction to gene expression datasets and GWAS summary statistics.
- Explanation of how to access and use genomic data.
- Overview of statistical methods used in TWAS.
- Detailed explanation of how to perform TWAS analysis: software and tools
- Interpretation of results: Manhattan plots and QQ plots
16:30 Session 2 –Exploring New Methods– Dennis Grishin, Dana-Farber Cancer Institute, Boston
- The significance of TWAS results in genetic research and medicine
- RWAS (Regulome-Wide Associations Study): integrating chromatin accessibility and allele specific signals
- Practical examples of risk variant Identification
17:15 Session 3 – Lecture –Transcriptomics as tool to investigate rare and common diseases, Stephen B Montgomery, Stanford University School of Medicine, Stanford
18:00 Conclusions
INFORMAZIONI CORSO
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Webinar non ECM in ingleseRESPONSABILE SCIENTIFICO
Prof. Mario CapassoCoordinatore GdL Multifattoriali
QUOTE DI ISCRIZIONE
ISCRIZIONE GRATUITA PER I SOCI SIGU IN REGOLA CON LA QUOTA 202430,00 EURO PIU' IVA PER I NON SOCI SIGU